ENCALADA LAB
Endolysosomal Membrane Trafficking and Neurodegeneration
ENCALADA LAB PUBLICATIONS
A list of our published work can also be found at PubMed:
http://www.ncbi.nlm.nih.gov/myncbi/sandra.encalada.1/bibliography/47914298/public/?sort=date&direction=ascending
bioRxiv | March 2023
Chaiamarit T, Verhelle A, Chassefeyre R, Shukla N, Novak SW, Andrade LR, Manor U, Encalada SE. 2023. Mutant prion protein endoggresomes are hubs for local axonal organelle-cytoskeletal remodeling. bioRxiv doi: https://doi.org/10.1101/2023.03.19.533383
Bio-Protocol | April 2023
Chaiamarit T., Wu Y., Verhelle A., Encalada S.E. 2023. Fluorescence assays for real-time tracking of cell surface protein internalization and endosomal sorting in axons of primary mouse hippocampal neurons. Bio-Protocol 13(07): e4651. DOI: 10.21769/BioProtoc.4651.
bioRxiv | September 2022
Yoon L., Botham R.C., Verhelle A., Sanz-Martinez P., Xu J., Cole C.M., Tan E.P., Chou C.C., Cuoco C.A., Massey L.A., Labra S., Elia L.P., Ta A., Ardejani M.S., Lee K., Kline G.M., Xiao Q., Cano-Franco S., Lyang N.J., Hou W.C., Yu A., Fox S., Ko Y., Wulkop-Gil C., Ibrahim L.H., Jiang S., Meneses A., Nelson L.T., Peng H., Lipton S.A., Bollong M.J., Hansen M., Morimoto R.I., Petrassi H.M., Wiseman R.L., Powers E.T., Finkbeiner S., Garza D., Finley D., Prado M.A., Dikic I., Frydman J.*, Johnson K.A.*, Silva M.C.*, Haggarty S.J.*, Stolz A.*, Encalada S.E.*, Kelly J.W.* 2022. mTOR inhibitor-independent autophagy activator ameliorates tauopathy and prionopathy neurodegeneration phenotypes. bioRxiv. Sept 30. doi.org/10.1101/2022.09.29.509997
* Co-corresponding authors.
Science Advances | December 2021
Chassefeyre R., Chaiamarit T., Verhelle A., Novak S.W., Andrade L.R., Leitao A.D.G., Manor U., Encalada S.E. 2021. Endosomal Sorting Drives the Formation of Mutant Prion Protein Endoggresomes. Cover article, Sci. Adv. Dec 22; 7(52), DOI: 10.1126/sciadv.abg3693.
bioRxiv version at: doi.org/10.1101/2020.09.27.315846
Comment on Faculty Opinions:
https://facultyopinions.com/prime/741357007
Autophagy | October 2021
Nieto-Torres J.L., Encalada S.E., Hansen M. 2021. LC3B phosphorylation: autophagosome's ticket for a ride toward the cell nucleus. Autophagy. Oct;17(10):3266-3268.
doi: 10.1080/15548627.2021.1961073. Epub 2021 Aug 23.
Current Biology | August 2021
Nieto-Torres J.L., Shanahan S-L., Chassefeyre R., Chaiamarit T., Zaretski S., Landeras-Bueno S., Verhelle A., Encalada S.E.*, Hansen M.* 2021. LC3 phosphorylation regulates FYCO1 binding and directional transport of autophagosomes. Current Biology. Aug 9;31(15):3440-3449.e7. doi: 10.1016/j.cub.2021.05.052 PubMed PMID: 34146484; NIHMSID:NIHMS1717570.
* Co-corresponding authors.
bioRxiv version at: doi.org/10.1101/2020.05.15.081638
Viruses | July 2021
Race B., Williams K., Baune C., Striebel J.F., Encalada S.E., Chesebro B. 2021. Deletion of Kif5c does not alter prion disease tempo or spread in mouse brain. Viruses. Jul;13(7), 1391. doi.org/10.3390/v13071391.
Human Molecular Genetics | May 2019
Butler V.J., Salazar D.A., Soriano-Castell D., Alves-Ferreira M., Dennissen F.J.A., Vohra M., Oses-Prieto J.A., Li K.H., Wang A.L., Jing B., Li B., Groisman A., Gutierrez E., Mooney S., Burlingame A.L., Ashrafi K., Mandelkow E-M., Encalada S.E., Kao A.W. 2019. Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport. Human Molecular Genetics. May 1;28(9):1498-1514. doi.org/10.1093/hmg/ddy442 PMID: 30590647. PMCID: PMC6489414
PNAS | July 2018
Madhivanan K., Greiner E.R., Alves-Ferreira M., Soriano-Castell D., Rouzbeh N., Aguirre C.A., Paulsson J.F., Chapman J., Jian X., Ooi F.K., Lemos C., Dillin A., Prahlad V., Kelly J.W., Encalada S.E. 2018. Cellular Clearance of Circulating Transthyretin Decreases Cell Non-Autonomous Proteotoxicity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. Jul 30;115(33) E7710-E7719. doi: 10.1073/pnas.1801117115. PMID:30061394. PMCID: PMC6099907.
Cited in EurekAlert!:
https://www.eurekalert.org/pub_releases/2018-08/sri-rlt080718.php
Traffic | October 2016
Neumann S., Chassefeyre R., Campbell G.E., Encalada S.E. 2017. KymoAnalyzer: a software tool for the quantitative analysis of intracellular transport in neurons. Traffic. Jan;18(1):71-88. doi: 10.1111/tra.12456. Epub 2016 Dec 11. PMCID: PMC5473519.
Click here to download the KymoAnalyzer software!
eLife | December 2015
Rangaraju S., Solis G.M., Thompson R.C., Gomez-Amaro R.L., Kurian L., Encalada S.E., Niculescu III A.B., Salomon D.R., Petrascheck M. 2015. Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality. eLife. Dec 1;4:e08833. doi: 10.7554/eLife.08833. PMCID: PMC4720515.
Nature Reviews Drug Discovery | September 2015
Eisele Y.S., Monteiro C., Fearns C., Encalada S.E., Wiseman R.L., Powers E.T., Kelly J.W. 2015. Targeting protein aggregation for the treatment of degenerative diseases. Nat Rev Drug Discov. Nov;14(11):759-80. doi: 10.1038/nrd4593. PMCID: PMC4628595
J Am Chem Soc | June 2015
Baranczak A., Liu Y., Connelly S., Han Du W-E., Greiner E.R., Genereux J.C., Wiseman R.L., Eisele Y.S., Bradbury N.C., Dong J., Noodleman L., Sharpless K.B., Wilson I.A., Encalada S.E.*, Kelly J.W.* 2015. A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans. J Am Chem Soc. Jun 17;137(23):7404-14. doi: 10.1021/jacs.5b03042. Epub 2015 Jun 8. PMCID: PMC4472559
*Co-corresponding Authors
JoVE | October 2014
Neumann S., Campbell G.E., Szpankowski L., Goldstein L.S.B., Encalada S.E.* 2014. Characterizing the composition of molecular motors on moving axonal cargo using “Cargo Mapping” analysis. J Vis Exp. Oct 30;(92):e52029. doi: 10.3791/52029 PMCID: PMC4353387.
*Corresponding Author
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Annual Review of Biophysics | May 2014
Encalada S.E.*, & Goldstein L.S.B.* 2014. Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration. Annu Rev Biophys. 141-69. doi.org/10.1146/annurev-biophys-051013-022746. PMID: 24702007. PMID: 24702007.
*Co-Corresponding authors
J Cell Sci | April 2014
Otero M.G., Alloatti M., Cromberg L.E., Almenar-Queralt A., Encalada S.E., Pozo Devoto V.M., Bruno L., Goldstein L.S.B., Falzone T.L. 2014. Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function. J Cell Sci. Apr 1;127(Pt 7):1537-49. doi: 10.1242/jcs.140780. PMID: 24522182.
PNAS | May 2012
Szpankowski L., Encalada S.E., Goldstein L.S.B. 2012. Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles. Proc Natl Acad Sci U S A. 2012May 29;109(22):8582-7. doi: 10.1073/pnas.1120510109. PMID: 22582169. PMCID: PMC3365224.
Cited in Faculty of 1000:
Stevens, D: http://f1000.com/prime/716397807
Cell | February 2011
Encalada S.E.*, Szpankowski L., Xia C.H., Goldstein L.S.B.* 2011. Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles. Cell. Feb 18;144(4):551-65. https://doi.org/10.1016/j.cell.2011.01.021. PMID: 21335237. PMCID: PMC3576050.
*Co-Corresponding authors
Cited in Faculty of 1000:
Sheng Z: http://f1000.com/prime/8671969
Kuta A, Fisher E: http://f1000.com/prime/8671969
Cited in Alzheimer Research Forum:
http://www.alzforum.org/pap/annotation.asp?powID=114594#
http://www.alzforum.org/new/detail.asp?id=2712
Featured in:
https://www.sciencedaily.com/releases/2011/02/110217125111.htm
Encalada S.E., Goldstein L.S.B. 2009. Axonal Transport of the Prion Protein and Prion Neuroinvasion. The New Encyclopedia of Neuroscience (Larry Squire, ed.). Elsevier, Oxford, UK, pp. 1071-1075.
Encalada S.E., Moya K.L., Lehmann S., Zahn R. 2007. The role of the prion protein in the molecular basis for synaptic plasticity and nervous system development. J Mol Neurosci. 34(1):9-15. Epub 2007 Jun 14. doi: 10.1007/s12031-007-0011-x. PMID: 18157653.
Encalada S.E., Willis J., Lyczak R., Bowerman B. 2005. A spindle checkpoint functions during mitosis in the early Caenorhabditis elegans embryo. Mol Biol Cell. Mar;16(3):1056-70. Epub 2004 Dec 22. (cover). doi: 10.1091/mbc.e04-08-0712. PMID: 15616189. PMCID: PMC551473.
Gomes J.E., Encalada S.E., Swan K.A., Shelton C.A., Carter J.C., Bowerman B. 2001. The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early Caenorhabditis elegans embryos. Development. 128(21):4301-14. PMID: 11684665.
Encalada S.E., Martin P.R., Phillips J.B., Lyczak R., Hamill D.R., Swan K.A., Bowerman B. 2000. DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos. Developmental Biology. Dec 15;228(2):225-38. doi: 10.1006/dbio.2000.9965. PMID: 11112326.
Fernando P., Pfrender M.E., Encalada S.E., Lande R. 2000. Mitochondrial DNA variation, phylogeography and population structure of the Asian elephant. Heredity (Edinb). Mar;84 ( Pt 3):362-72. doi: 10.1046/j.1365-2540.2000.00674.x. PMID: 10762406.
Encalada S.E., Zurita J.C., Bowen B.W. 1999. Genetic consequences of coastal development: the sea turtle rookeries at X’cacel Mexico. Marine Turtle Newsletter. 83:8-10.
Bolten A.B., Bjorndal K.A., Martins H.R., Dellinger T., Biscoito M.J., Encalada S.E., Bowen B.W. 1998. Transatlantic developmental migrations of loggerhead sea turtles demonstrated by mtDNA sequence analysis. Ecological Applications. 8:1-7.
Encalada S.E., Bjorndal K.A., Bolten A.B., Zurita J.C., Schroeder B., Possardt, E., Sears C.J., Bowen B.W. 1998. Population structure of loggerhead turtle (Caretta caretta) nesting colonies in the Atlantic and Mediterranean as inferred from mitochondrial DNA control region sequences. Marine Biology. 1130:567-575.
Lahanas P.N., Bjorndal K.A,. Bolten A.B., Encalada S.E., Miyamoto M.M., Valverde R.A., Bowen B.W. 1998. Genetic composition of a green turtle (Chelonia mydas) feeding ground population: evidence for multiple origins. Marine Biology 130:345-352.
Rankin-Baransky K., Williams C.J., Bowen B.W., Encalada S.E., Spotila J.R. 1998. Origin of loggerhead sea turtles in the western north Atlantic as determined by mtDNA analysis. In: Proceedings of the Seventeenth Annual Sea Turtle Symposium. (Epperly, S. P., and Braun, J. Compilers), U.S. Dep. Commer. NOAA Tech Memo. NMFS-SEFSC-415. 294 pp.; 1998, p. 79. doi: 10.2307/1565903
Encalada S.E., Lahanas P.N., Bjorndal K.A., Bolten A.B., Miyamoto M.M., Bowen B.W. 1996. Phylogeography and population structure of the green turtle (Chelonia mydas) in the Atlantic Ocean and Mediterranean Sea: a mitochondrial DNA control region assessment. Molecular Ecology. Aug;5(4):473-83. PMID: 8794558.
Encalada S.E. 1996. Conservation genetics of Atlantic green turtles: cases of imminent rookery extinctions. In: Proceedings of the First Sea Turtle Genetics Symposium (Bowen, B. W., and W. N. Witzell, eds). NOAA Technical Memorandum NMFS-SEFSC-396, pp33-40.
Abreu-Grobois F.A., Bass A.L., Dutton P.H., Encalada S.E. 1996. PCR-RFLP analysis of sea turtle populations in the era of DNA sequencing: is it still useful? In: Proceedings of the First Sea Turtle Genetics Symposium (Bowen, B. W., and W. N. Witzell, eds). NOAA Technical Memorandum NMFS-SEFSC-396, pp55-67.
Encalada S.E., Eckert S.A., Bowen B.W. 1994. Forensic applications of mitochondrial DNA markers: origin of a confiscated green turtle. Marine Turtle Newsletter. 66:1-3. [Link]
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