ENCALADA LAB
Intracellular Endolysosomal Transport and Neurodegeneration
ENCALADA LAB PUBLICATIONS
A list of our published work can also be found at PubMed:
http://www.ncbi.nlm.nih.gov/myncbi/sandra.encalada.1/bibliography/47914298/public/?sort=date&direction=ascending
Bio-Protocol | In review 2022
Chaiamarit T, Verhelle A, Encalada SE. Fluorescence live imaging assays to characterize cell surface protein internalization and endosomal sorting in axons of primary mouse hippocampal neurons. In review.
bioRxiv | September 2022
Yoon L, Botham RC, Verhelle A, Sanz-Martinez P, Xu J, Cole CM, Tan EP, Chou CC, Cuoco CA, Massey LA, Labra S, Elia LP, Ta A, Ardejani MS, Lee K, Kline GM, Xiao Q, Cano-Franco S, Lyang NJ, Hou WC, Yu A, Fox S, Ko Y, Wulkop-Gil C, Ibrahim LH, Jiang S, Meneses A, Nelson LT, Peng H, Lipton SA, Bollong MJ, Hansen M, Morimoto RI, Petrassi HM, Wiseman RL, Powers ET, Finkbeiner S, Garza D, Finley D, Prado MA, Dikic I, Frydman J*, Johnson KA*, Silva MC*, Haggarty SJ*, Stolz A*, Encalada SE*, Jeffery W. Kelly*. mTOR inhibitor-independent autophagy activator ameliorates tauopathy and prionopathy neurodegeneration phenotypes.
bioRxiv doi.org/10.1101/2022.09.29.509997
* Co-corresponding authors.
Science Advances | December 2021
Chassefeyre R, Chaiamarit T, Verhelle A, Novak SW, Andrade LR, Leitao ADG, Manor U, Encalada SE. 2021. Endosomal Sorting Drives the Formation of Mutant Prion Protein Endoggresomes. Cover article, Sci. Adv. 7(52), DOI: 10.1126/sciadv.abg3693.
Comment on Faculty Opinions:
https://facultyopinions.com/prime/741357007
Autophagy | October 2021
Nieto-Torres JL, Encalada SE, Hansen M. 2021. LC3B phosphorylation: autophagosome's ticket for a ride toward the cell nucleus. Autophagy, Oct;17(10):3266-3268.
doi: 10.1080/15548627.2021.1961073. Epub 2021 Aug 23.
Current Biology | August 2021
Nieto-Torres JL, Shanahan S-L, Chassefeyre R, Landeras-Bueno S, Encalada SE*, Hansen M*. 2021. LC3 phosphorylation regulates FYCO1 binding and directional transport of autophagosomes. Current Biology Aug 9;31(15):3440-3449.e7. doi: 10.1016/j.cub.2021.05.052 PubMed PMID: 34146484; NIHMSID:NIHMS1717570.
* Co-corresponding authors.
Viruses | July 2021
Race B, Williams K, Baune C, Striebel JF, Encalada SE, Chesebro B. 2021. Deletion of Kif5c does not alter prion disease tempo or spread in mouse brain. Viruses 13(7), 1391 doi.org/10.3390/v13071391.
Human Molecular Genetics | May 2019
Butler VJ, Salazar DA, Soriano-Castell D, Alves-Ferreira M, Dennissen FJA, Vohra M, Oses-Prieto JA, Li KH, Wang AL, Jing B, Li B, Groisman A, Gutierrez E, Mooney S, Burlingame AL, Ashrafi, K, Mandelkow E-M, Encalada SE, Kao AW. 2019. Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport. Human Molecular Genetics. 2019 May 1;28(9):1498-1514. doi.org/10.1093/hmg/ddy442 PMID: 30590647. PMCID: PMC6489414
PNAS | July 2018
Madhivanan K, Greiner ER, Alves-Ferreira M, Soriano-Castell D, Rouzbeh N, Aguirre CA, Paulsson JF, Chapman J, Jian X, Ooi FK, Lemos C, Dillin A, Prahlad V, Kelly JW, Encalada SE. 2018. Cellular Clearance of Circulating Transthyretin Decreases Cell Non-Autonomous Proteotoxicity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. Jul 30. pii: 201801117. doi: 10.1073/pnas.1801117115. PMID:30061394. PMCID: PMC6099907.
Cited in EurekAlert!:
https://www.eurekalert.org/pub_releases/2018-08/sri-rlt080718.php
Traffic | October 2016
Neumann S, Chassefeyre R, Campbell GE, Encalada SE. 2017. KymoAnalyzer: a software tool for the quantitative analysis of intracellular transport in neurons. Traffic Jan;18(1):71-88. doi: 10.1111/tra.12456. Epub 2016 Dec 11. PMCID: PMC5473519.
Click here to download the KymoAnalyzer software!
eLife | December 2015
Rangaraju S, Solis GM, Thompson RC, Gomez-Amaro RL, Kurian L, Encalada SE, Niculescu III, AB, Salomon DR, Petrascheck M. 2015. Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality. eLife Dec 1;4:e08833. doi: 10.7554/eLife.08833. PMCID: PMC4720515.
Nature Reviews Drug Discovery | September 2015
Eisele YS, Monteiro C, Fearns C, Encalada SE, Wiseman RL, Powers ET, Kelly JW. 2015. Targeting protein aggregation for the treatment of degenerative diseases. Nat Rev Drug Discov. Nov;14(11):759-80. doi: 10.1038/nrd4593. PMCID: PMC4628595
J Am Chem Soc | June 2015
Baranczak A, Liu Y, Connelly S, Han Du W-E, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE*, Kelly JW* 2015. A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans. J Am Chem Soc. 2015 Jun 17;137(23):7404-14. doi: 10.1021/jacs.5b03042. Epub 2015 Jun 8. PMCID: PMC4472559
*Co-corresponding Authors
JoVE | October 2014
Neumann S., Campbell G.E., Szpankowski L., Goldstein L.S.B., Encalada S.E.* 2014. Characterizing the composition of molecular motors on moving axonal cargo using “Cargo Mapping” analysis. J Vis Exp. Oct 30;(92):e52029. doi: 10.3791/52029 PMCID: PMC4353387.
*Corresponding Author
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Annual Review of Biophysics | May 2014
Encalada S.E.*, & Goldstein L.S.B.* 2014. Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration. Annu Rev Biophys. 141-69. doi.org/10.1146/annurev-biophys-051013-022746. PMID: 24702007. PMID: 24702007.
*Co-Corresponding authors
J Cell Sci | April 2014
Otero MG, Alloatti M, Cromberg LE, Almenar-Queralt A, Encalada SE, Pozo Devoto VM, Bruno L, Goldstein LSB, Falzone TL 2014. Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function. J Cell Sci. 2014 Apr 1;127(Pt 7):1537-49. doi: 10.1242/jcs.140780. PMID: 24522182.
PNAS | May 2012
Szpankowski L., Encalada S.E., Goldstein L.S.B. 2012. Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8582-7. doi: 10.1073/pnas.1120510109. PMID: 22582169. PMCID: PMC3365224.
Cited in Faculty of 1000:
Stevens, D: http://f1000.com/prime/716397807
Cell | February 2011
Encalada SE*, Szpankowski L, Xia CH, Goldstein LSB*. 2011. Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles. Cell Feb 18;144(4):551-65. https://doi.org/10.1016/j.cell.2011.01.021. PMID: 21335237. PMCID: PMC3576050.
*Co-Corresponding authors
Cited in Faculty of 1000:
Sheng Z: http://f1000.com/prime/8671969
Kuta A, Fisher E: http://f1000.com/prime/8671969
Cited in Alzheimer Research Forum:
http://www.alzforum.org/pap/annotation.asp?powID=114594#
http://www.alzforum.org/new/detail.asp?id=2712
Featured in:
https://www.sciencedaily.com/releases/2011/02/110217125111.htm
Encalada SE, Goldstein LSB. 2009. Axonal Transport of the Prion Protein and Prion Neuroinvasion. The New Encyclopedia of Neuroscience (Larry Squire, ed.). 2009. Elsevier, Oxford, UK, pp. 1071-1075.
Encalada SE, Moya KL, Lehmann S, Zahn R. 2007. The role of the prion protein in the molecular basis for synaptic plasticity and nervous system development. J Mol Neurosci. 2008;34(1):9-15. Epub 2007 Jun 14. doi: 10.1007/s12031-007-0011-x. PMID: 18157653.
Encalada SE, Willis J, Lyczak R, Bowerman B. 2005. A spindle checkpoint functions during mitosis in the early Caenorhabditis elegans embryo. Mol Biol Cell. Mar;16(3):1056-70. Epub 2004 Dec 22. (cover). doi: 10.1091/mbc.e04-08-0712. PMID: 15616189. PMCID: PMC551473.
Gomes JE, Encalada SE, Swan KA, Shelton CA, Carter JC, Bowerman B. 2001. The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early Caenorhabditis elegans embryos. Development Nov;128(21):4301-14. PMID: 11684665.
Encalada SE, Martin PR, Phillips JB, Lyczak R, Hamill DR, Swan KA, Bowerman B. 2000. DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos. Developmental Biology Dec 15;228(2):225-38. doi: 10.1006/dbio.2000.9965. PMID: 11112326.
Fernando P., Pfrender M.E., Encalada S.E., Lande R. 2000. Mitochondrial DNA variation, phylogeography and population structure of the Asian elephant. Heredity (Edinb). Mar;84 ( Pt 3):362-72. doi: 10.1046/j.1365-2540.2000.00674.x. PMID: 10762406.
Encalada S.E., Zurita J.C., Bowen B.W. 1999. Genetic consequences of coastal development: the sea turtle rookeries at X’cacel Mexico. Marine Turtle Newsletter 83:8-10.
Bolten A.B., Bjorndal K.A., Martins H.R., Dellinger T., Biscoito M.J., Encalada S.E., Bowen B.W. 1998. Transatlantic developmental migrations of loggerhead sea turtles demonstrated by mtDNA sequence analysis. Ecological Applications 8:1-7.
Encalada S.E., Bjorndal K.A., Bolten A.B., Zurita J.C., Schroeder B., Possardt, E., Sears C.J., Bowen B.W. 1998. Population structure of loggerhead turtle (Caretta caretta) nesting colonies in the Atlantic and Mediterranean as inferred from mitochondrial DNA control region sequences. Marine Biology 1130:567-575.
Lahanas P.N., Bjorndal K.A,. Bolten A.B., Encalada S.E., Miyamoto M.M., Valverde R.A., Bowen B.W. 1998. Genetic composition of a green turtle (Chelonia mydas) feeding ground population: evidence for multiple origins. Marine Biology 130:345-352.
Rankin-Baransky K., Williams C.J., Bowen B.W., Encalada S.E., Spotila J.R. 1998. Origin of loggerhead sea turtles in the western north Atlantic as determined by mtDNA analysis. In: Proceedings of the Seventeenth Annual Sea Turtle Symposium. (Epperly, S. P., and Braun, J. Compilers), U.S. Dep. Commer. NOAA Tech Memo. 1998 NMFS-SEFSC-415. 294 pp.; 1998, p. 79. doi: 10.2307/1565903
Encalada S.E, Lahanas P.N., Bjorndal K.A., Bolten A.B., Miyamoto M.M., Bowen B.W. 1996. Phylogeography and population structure of the green turtle (Chelonia mydas) in the Atlantic Ocean and Mediterranean Sea: a mitochondrial DNA control region assessment. Molecular Ecology Aug;5(4):473-83. PMID: 8794558.
Encalada S.E. 1996. Conservation genetics of Atlantic green turtles: cases of imminent rookery extinctions. In: Proceedings of the First Sea Turtle Genetics Symposium (Bowen, B. W., and W. N. Witzell, eds). NOAA Technical Memorandum NMFS-SEFSC-396, pp33-40.
Abreu-Grobois F.A., Bass A.L., Dutton P.H., Encalada S.E. 1996. PCR-RFLP analysis of sea turtle populations in the era of DNA sequencing: is it still useful? In: Proceedings of the First Sea Turtle Genetics Symposium (Bowen, B. W., and W. N. Witzell, eds). NOAA Technical Memorandum NMFS-SEFSC-396, pp55-67.
Encalada S.E., Eckert S.A., Bowen B.W. 1994. Forensic applications of mitochondrial DNA markers: origin of a confiscated green turtle. Marine Turtle Newsletter 66:1-3. [Link]
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